“Myriad was able to isolate the BRCA genes in the first place largely because it had access to government-financed public databases.”

Eleonore Pauwels, from “Our Genes, Their Secrets” [New York Times]

Once again, public financing was lost in the conversation.

UC Berkeley professor Steven E. Brenner lets you construct a personalized annotated version of a text he wrote for the journal Nature on mitigating the potential dangers of genome leaks. [Comp Bio | Berkeley]
From the FAQ at the link above,

What is this document?
Collected jetsam. I submitted a rough piece to Nature, and the editor there helped whip it into shape and cut it down to size. Along the way, bits of text were left on the cutting room floor. I’ve collected some of those elisions that help motivate or explicate my points, as well as expanded on some queries I received. This document does not purport to be a full-fledged support of every detail in the piece. Why are you providing this annotation in such a weird form?
Natureowns the copyright on my piece, and they were firm that I could not post the text anywhere else for 6 months, even for the sole purpose of providing the annotation. This print overlay was designed as a method that could be used by anyone to make an annotated version, without any special technology beyond a PDF viewer and a printer. Let me know if you have better ideas for how to legally distribute the annotations.


Interesting method to say, I‘m not finished and it probably beats a blog post. UC Berkeley professor Steven E. Brenner lets you construct a personalized annotated version of a text he wrote for the journal Nature on mitigating the potential dangers of genome leaks. [Comp Bio | Berkeley]
From the FAQ at the link above,

What is this document?
Collected jetsam. I submitted a rough piece to Nature, and the editor there helped whip it into shape and cut it down to size. Along the way, bits of text were left on the cutting room floor. I’ve collected some of those elisions that help motivate or explicate my points, as well as expanded on some queries I received. This document does not purport to be a full-fledged support of every detail in the piece. Why are you providing this annotation in such a weird form?
Natureowns the copyright on my piece, and they were firm that I could not post the text anywhere else for 6 months, even for the sole purpose of providing the annotation. This print overlay was designed as a method that could be used by anyone to make an annotated version, without any special technology beyond a PDF viewer and a printer. Let me know if you have better ideas for how to legally distribute the annotations.


Interesting method to say, I‘m not finished and it probably beats a blog post. UC Berkeley professor Steven E. Brenner lets you construct a personalized annotated version of a text he wrote for the journal Nature on mitigating the potential dangers of genome leaks. [Comp Bio | Berkeley]
From the FAQ at the link above,

What is this document?
Collected jetsam. I submitted a rough piece to Nature, and the editor there helped whip it into shape and cut it down to size. Along the way, bits of text were left on the cutting room floor. I’ve collected some of those elisions that help motivate or explicate my points, as well as expanded on some queries I received. This document does not purport to be a full-fledged support of every detail in the piece. Why are you providing this annotation in such a weird form?
Natureowns the copyright on my piece, and they were firm that I could not post the text anywhere else for 6 months, even for the sole purpose of providing the annotation. This print overlay was designed as a method that could be used by anyone to make an annotated version, without any special technology beyond a PDF viewer and a printer. Let me know if you have better ideas for how to legally distribute the annotations.


Interesting method to say, I‘m not finished and it probably beats a blog post.

UC Berkeley professor Steven E. Brenner lets you construct a personalized annotated version of a text he wrote for the journal Nature on mitigating the potential dangers of genome leaks. [Comp Bio | Berkeley]

From the FAQ at the link above,

What is this document?

Collected jetsam. I submitted a rough piece to Nature, and the editor there helped whip it into shape and cut it down to size. Along the way, bits of text were left on the cutting room floor. I’ve collected some of those elisions that help motivate or explicate my points, as well as expanded on some queries I received. This document does not purport to be a full-fledged support of every detail in the piece.

Why are you providing this annotation in such a weird form?

Natureowns the copyright on my piece, and they were firm that I could not post the text anywhere else for 6 months, even for the sole purpose of providing the annotation. This print overlay was designed as a method that could be used by anyone to make an annotated version, without any special technology beyond a PDF viewer and a printer. Let me know if you have better ideas for how to legally distribute the annotations.

Interesting method to say, I‘m not finished and it probably beats a blog post.

“A more important consequence than random coin tosses is the uncertainty that is the basis of the random DNA mutations necessary for evolution. A truly indeterminate local physics guarantees that this process has some “noise,” and that mutation is always possible in principle. The chemistry of DNA replication involves, after all, exchanges of electrons and atoms, which are quantum objects.”
The Rise of the Uncertain [Nautilus]
“The U.S. government’s investment of $14.5 billion in human genome science has helped to spur nearly $1 trillion in economic activity and create tens of thousands of jobs over the past 24 years, according to a new study.”

Genome Science Said to Have Economic Payoff [WSJ]

Despite all of the noise around the human genome, here’s an interesting tidbit,

In 1990, for example, only 61 diseases or health conditions had an identified cause linked to genes; today, there about 4,850, according to United for Medical Research, an advocacy group, which funded the latest study.

And the number is expected to increase as statistical methods are improved upon and more genome sequences become available.

Tumblr’s Mad Geneticist wrote a bit about the differences between genotyping (think 23&Me, ancestry stuff) and sequencing (the raw, good stuff).

pritheworld:

dbaldinger:

New cartoon: GMO Danger

Are GMOs a technology we should consider to cope with climate change? We’ll examine the issue on today’s show.

I love that this is a debate when the answer to the question is clearly a yes. It should be considered, at the very least a consideration should be reserved for such a huge problem.

From a recent London Review of Books article on climate change,

A recent Unicef briefing reiterated the obvious but important point that the world’s poorest children are the most vulnerable to climate change. The report’s recommendations include ‘providing crops that are more drought resistant to smallholder families in areas that are increasingly prone to drought.’ Unicef doesn’t spell it out, but drought-resistant crops probably means genetically modified crops.

The question, Are GMOs a technology we should consider to cope with climate change?, obviously lends itself to an answer.

“I join the judgment of the Court, and all of its opinion except Part I–A and some portions of the rest of the opinion going into fine details of molecular biology. I am unable to affirm those details on my own knowledge or even my own belief. It suffices for me to affirm, having studied the opinions below and the expert briefs presented here, that the portion of DNA isolated from its natural state sought to be patented is identical to that portion of the DNA in its natural state; and that complementary DNA (cDNA) is a synthetic creation not normally present in nature.”

A big-deal case passed the Supreme Court this morning, with the court finding that genes can’t be patented. But the fun part of this decision is Justice Antonin Scalia’s reasoning for joining with the majority, which disregards a part of the opinion which notes that “Genes form the basis for hereditary traits in living organisms.” Apparently Scalia slept through biology class in high school, because that’s all way over his head.

By way of shortformblog.

(via shortformblog)